Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357941 | 0.87 | MAPT (0.48) | MAPTCACNA1BCA1CA2LMNA | |
| SCHEMBL8358041 | 0.86 | KMT2A (0.52) | MAPTCA1CA2CSNK1DLMNA | |
| SCHEMBL8359111 | 0.86 | CACNA1B (0.53) | MAPTCACNA1BCACNA1HCSNK1DLMNA | |
| SCHEMBL8551381 | 0.85 | CACNA1B (0.45) | MAPTCACNA1BCACNA1HCA1CA2 | |
| SCHEMBL8355815 | 0.85 | KMT2A (0.47) | MAPTCA1CA2CSNK1DEPHX2 | |
| SCHEMBL8359679 | 0.83 | MAPT (0.61) | MAPTCSNK1DCYP1A2CYP3A4TSHR | |
| SCHEMBL8551252 | 0.82 | LMNA (0.50) | MAPTCACNA1BCACNA1HCA1CA2 | |
| SCHEMBL8551665 | 0.81 | CACNA1B (0.47) | MAPTCACNA1BCACNA1HCA1CA2 | |
| SCHEMBL8550957 | 0.80 | CACNA1B (0.44) | MAPTCACNA1BCACNA1HLMNACYP1A2 | |
| SCHEMBL29016615 | 0.79 | EPHX2 (0.44) | MAPTCSNK1DSCN4AEPHX2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919807-A | ANTICHOLESTEROL AGENTS | DR. KARL THOMAE GMBH (DE) | 1999-07-06 | — | — | US | disclosed |
| EP-0824529-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035681-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-11-14 | — | — | WO | disclosed |