SCHEMBL8359564

SCHEMBL8359564

CCOc1nc2c(C)c(C)c(C)nc2n1-c1ccc(-c2ccccc2-c2nc(=S)o[nH]2)cc1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.32
PPARG P37231 1/20 0.32
LMNA P02545 1/20 0.32
PDE5A O76074 1/20 0.31
MAT2A P31153 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
HPGD P15428 2/20 0.31
CACNA2D1 P54289 1/20 0.31
PRNP P04156 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
KMT2A Q03164 1/20 0.30
FFAR4 Q5NUL3 1/20 0.30
P2RX4 Q99571 1/20 0.30
AGTR2 P50052 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8363470 0.93 PDE5A (0.32) AGTR1PPARGPDE5AFFAR4ALDH1A1
SCHEMBL8363421 0.90 KDM4E (0.34) PPARGLMNASMN1; SMN2HPGDPRNP
SCHEMBL8363428 0.89 AGTR1 (0.40) AGTR1PPARGP2RX4AGTR2
SCHEMBL8364105 0.86 AGTR1 (0.35) AGTR1PPARGSMN1; SMN2KMT2AFFAR4
SCHEMBL8364598 0.84 PI4KA (0.35) AGTR1PPARGAGTR2
SCHEMBL8364088 0.84 LMNA (0.32) AGTR1PPARGLMNAMAT2ASMN1; SMN2
SCHEMBL8359446 0.82 AGTR1 (0.33) AGTR1PPARGAGTR2
SCHEMBL8361967 0.80 MAT2A (0.34) LMNAPDE5AMAT2ASMN1; SMN2HPGD
SCHEMBL8587441 0.79 AGTR2 (0.35) AGTR1PPARGLMNASMN1; SMN2AGTR2
SCHEMBL8586719 0.75 AGTR1 (0.35) AGTR1PPARGPDE5ASMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5883111-A STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-03-16 US disclosed
US-5736555-A HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-04-07 US disclosed