SCHEMBL837432

SCHEMBL837432

N=C(NC(=N)N(CCN(C(=N)NC(=N)Nc1ccccc1)c1ccccc1)c1ccccc1)Nc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.45
KMT2A Q03164 5/20 0.45
HSD17B10 Q99714 2/20 0.43
USP2 O75604 1/20 0.43
CYP3A4 P08684 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TP53 P04637 2/20 0.37
HTT P42858 1/20 0.37
ALDH1A1 P00352 3/20 0.36
ADRB2 P07550 1/20 0.36
HPGD P15428 1/20 0.36
MAPT P10636 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
THRB P10828 1/20 0.35
PKM P14618 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
NOX1 Q9Y5S8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL836169 0.77 MEN1 (0.44) MEN1KMT2AHSD17B10USP2CYP3A4
SCHEMBL4097943 0.77 KMT2A (0.53) MEN1KMT2AHSD17B10USP2TP53
SCHEMBL1743216 0.75 TAS2R38 (0.50) MEN1KMT2AHSD17B10CYP3A4SMN1; SMN2
SCHEMBL14868330 0.75 TAS2R38 (0.41) MEN1KMT2AHSD17B10CYP3A4SMN1; SMN2
SCHEMBL7787793 0.72 KMT2A (0.65) MEN1KMT2AHSD17B10USP2TP53
SCHEMBL837036 0.72 NPC1 (0.47) SMN1; SMN2TP53HTTALDH1A1HPGD
SCHEMBL837588 0.71 MEN1 (0.41) MEN1KMT2AHSD17B10USP2CYP3A4
SCHEMBL35172 0.71 HSD17B10 (0.55) MEN1KMT2AHSD17B10CYP3A4SMN1; SMN2
SCHEMBL20163213 0.71 HSD17B10 (0.55) MEN1KMT2AHSD17B10CYP3A4SMN1; SMN2
SCHEMBL10728982 0.69 L3MBTL1 (0.49) MEN1KMT2ASMN1; SMN2TP53HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3174446-B1 A METHOD OF MANUAL SURFACE CLEANING USING CLEANING TEXTILES AND OF WASHING SAID CLEANING TEXTILES ECOLAB USA INC (US) 2019-01-30 EP disclosed
US-20170209016-A1 METHOD OF MANUAL SURFACE CLEANING USING CLEANING TEXTILES AND OF WASHING SAID CLEANING TEXTILES ECOLAB USA INC. 2017-07-27 US disclosed
EP-3174446-A1 A METHOD OF MANUAL SURFACE CLEANING USING CLEANING TEXTILES AND OF WASHING SAID CLEANING TEXTILES Ecolab USA Inc. (US) 2017-06-07 EP disclosed
EP-3083916-A1 DISINFECTANT COMPOSITION WITH EXCELLENT FOAM PROFILE AND CLEANING POWER Henkel AG & Co. KGaA (DE) 2016-10-26 EP disclosed
WO-2015091164-A1 DISINFECTANT COMPOSITION WITH EXCELLENT FOAM PROFILE AND CLEANING POWER HENKEL AG & CO. KGAA (DE) 2015-06-25 WO disclosed
WO-2015091163-A1 DISINFECTANT COMPOSITION WITH EXCELLENT FOAM PROFILE HENKEL AG & CO. KGAA (DE) 2015-06-25 WO disclosed
US-8143207-B2 Biocidal textile treatment agent HENKEL AG & CO. KGAA (DE) 2012-03-27 US disclosed
US-7985570-B2 Alkaline proteases and detergents and cleaners comprising these alkaline proteases B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK A.G. (DE) 2011-07-26 US disclosed
US-20100298198-A1 Alkaline Proteases and Detergents and Cleaners Comprising These Alkaline Proteases HENKEL KGAA (DE) 2010-11-25 US disclosed
US-7807616-B2 Geranonitrile substitute HENKEL AG & CO. KGAA (DE) 2010-10-05 US disclosed
US-20050113273-A1 Alkaline protease from bacillus gibsonii (DSM 14393) and washing and cleaning products comprising said alkaline protease HENKEL AG & CO. KGAA (DE) 2005-05-26 US disclosed
US-20050043198-A1 Alkaline protease from Bacillus sp. (DSM 14392) and washing and cleaning products comprising said alkaline protease HENKEL AG & CO. KGAA (DE) 2005-02-24 US disclosed
US-20050009167-A1 Alkaline protease from Bacillus sp. (DSM 14390) and washing and cleaning products comprising said alkaline protease HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2005-01-13 US disclosed
US-20050003504-A1 Alkaline protease from Bacillus gibsonii (DSM 14391) and washing and cleaning products comprising said alkaline protease HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2005-01-06 US disclosed
US-20050003985-A1 Alkaline protease variants HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2005-01-06 US disclosed
US-20050003419-A1 Glycosyl hydrolases B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) 2005-01-06 US disclosed
US-20040087475-A1 Quaternary ammonium softener, polyethersiloxane spreading agent and silicone oil ironability enhancer; textile laundering; nonstaining HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2004-05-06 US disclosed
US-20040031107-A1 Cleaning material HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL HGAA) (DE) 2004-02-19 US disclosed
WO-2001085896-A1 CONCENTRATE FOR DILUTION WITH MAINTENANCE OF OR AN INCREASE IN VISCOSITY HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2001-11-15 WO disclosed
US-20010031714-A1 Laundry, dishwashing or cleaning product detergent portions with controlled release of active substance HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009167-A1 Alkaline protease from Bacillus sp. (DSM 14390) and washing and cleaning products comprising said alkaline protease ANPEP, TMPRSS15, RNPEP MEN1 2427/4885KMT2A 2700/4885HSD17B10 1025/4885
US-20050043198-A1 Alkaline protease from Bacillus sp. (DSM 14392) and washing and cleaning products comprising said alkaline protease ANPEP, RNPEP, TMPRSS15 MEN1 2422/4885KMT2A 2103/4885HSD17B10 2417/4885
US-20050003419-A1 Glycosyl hydrolases AGL, ENGASE, UNG MEN1 2367/4885KMT2A 2364/4885HSD17B10 838/4885
US-20050113273-A1 Alkaline protease from bacillus gibsonii (DSM 14393) and washing and cleaning products comprising said alkaline protease PRSS2, ALPI, GBA3 MEN1 2013/4885KMT2A 3199/4885HSD17B10 1159/4885
US-20050003504-A1 Alkaline protease from Bacillus gibsonii (DSM 14391) and washing and cleaning products comprising said alkaline protease ALPI, RNPEP, PRSS2 MEN1 2184/4885KMT2A 2946/4885HSD17B10 1217/4885
US-20050003985-A1 Alkaline protease variants LCT, TMPRSS11D, CTRL MEN1 3322/4885KMT2A 920/4885HSD17B10 2084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.