SCHEMBL8374758

SCHEMBL8374758

Fc1cccc(F)c1C(Cl)=NN=C(Cl)c1c(F)cccc1F

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.48
CES1 P23141 3/20 0.48
ALDH1A1 P00352 1/20 0.38
ALOX15 P16050 1/20 0.38
LMNA P02545 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
GAA P10253 5/20 0.35
TDP1 Q9NUW8 2/20 0.34
JAK2 O60674 2/20 0.33
JAK1 P23458 2/20 0.33
TYK2 P29597 2/20 0.33
HTT P42858 1/20 0.33
NOD2 Q9HC29 1/20 0.33
BCHE P06276 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20136432 0.83 CES2 (0.46) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL5775733 0.83 CES2 (0.46) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL10332608 0.83 CES2 (0.46) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL8376199 0.82 ALDH1A1 (0.39) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL8376198 0.82 ALDH1A1 (0.39) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL7537026 0.80 L3MBTL1 (0.39) CES2CES1LMNAGAA
SCHEMBL7537020 0.80 L3MBTL1 (0.39) CES2CES1LMNAGAA
SCHEMBL20560251 0.72 CES2 (0.50) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL105255 0.72 CES2 (0.64) CES2CES1ALDH1A1ALOX15LMNA
SCHEMBL12156386 0.72 CES2 (0.50) CES2CES1ALDH1A1ALOX15LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0635499-B1 Novel acaricidally active tetrazine derivatives CHINOIN GYOGYSZER ES VEGYESZET (HU) 1999-03-03 EP disclosed
US-5587370-A MITICIDES CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYAR RT. (HU) 1996-12-24 US disclosed
US-5455237-A Larvicides, ovicides CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1995-10-03 US disclosed
EP-0635499-A2 Novel acaricidally active tetrazine derivatives CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1995-01-25 EP disclosed