SCHEMBL8377752

SCHEMBL8377752

O=c1ccn(CS)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.51
CRBN Q96SW2 3/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
DUT P33316 10/20 0.45
DDB1 Q16531 1/20 0.44
ENPP1 P22413 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5024016 0.83 L3MBTL1 (0.53) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL4348697 0.82 L3MBTL1 (0.59) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL5016828 0.80 DUT (0.55) PKMCRBNL3MBTL1DUT
SCHEMBL6102943 0.80 CRBN (0.56) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL1923335 0.78 PKM (0.61) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL338055 0.78 ALDH1A1 (0.56) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL10618034 0.78 PKM (0.51) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL4372127 0.78 PKM (0.51) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL8377765 0.78 PKM (0.51) PKMCRBNL3MBTL1ALDH1A1LMNA
SCHEMBL12482845 0.78 PKM (0.51) PKMCRBNL3MBTL1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0898575-A2 A COMBINATORIAL PROTECTING GROUP STRATEGY FOR MULTIFUNCTIONAL MOLECULES KÖSTER, Hubert (US) 1999-03-03 EP claimed
WO-1997041139-A2 A COMBINATORIAL PROTECTING GROUP STRATEGY FOR MULTIFUNCTIONAL MOLECULES KOESTER HUBERT (US) 1997-11-06 WO claimed
US-4211562-A Photographic compositions with silver halide solvents containing thioether groups POLAROID CORPORATION (US) 1980-07-08 US disclosed
US-4211559-A Photographic processes and compositions employing thioether containing silver halide solvents TEXAS INSTRUMENTS INCORPORATED (US) 1980-07-08 US disclosed
US-4150228-A PHOTOGRAPHIC COMPLEXING AGENTS POLAROID CORPORATION (US) 1979-04-17 US disclosed
US-4126459-A COMPLEXING AGENT FOR USE IN PHOTOGRAPHY POLAROID CORPORATION (US) 1978-11-21 US disclosed