Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838608 | 0.84 | PLOD2 (0.57) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL11099262 | 0.84 | P2RX7 (0.51) | LMNAGALR3NR2F2KMT2AP2RX7 | |
| SCHEMBL836320 | 0.82 | L3MBTL1 (0.62) | ALDH1A1GALR3NR2F2MEN1KMT2A | |
| SCHEMBL5318479 | 0.82 | MAPT (0.57) | ALDH1A1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL27997536 | 0.80 | L3MBTL1 (0.71) | ALDH1A1LMNAKDM4EPKMMEN1 | |
| SCHEMBL11825208 | 0.79 | TSHR (0.62) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL11823899 | 0.78 | NPC1 (0.65) | ALDH1A1LMNAKDM4EPKMMEN1 | |
| SCHEMBL2847244 | 0.78 | MAPT (0.55) | LMNARAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL31692743 | 0.77 | PLOD2 (0.49) | ALDH1A1LMNAKDM4EPKMMEN1 | |
| SCHEMBL11096668 | 0.77 | GALR3 (0.53) | GALR3NR2F2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062238-B1 | 1,3-DIOXOLANE DERIVATIVES, THEIR PREPARATION, FUNGICIDAL AGENTS CONTAINING THOSE COMPOUNDS AS ACTIVE AGENTS AND USE OF SUCH COMPOUNDS OR AGENTS IN COMBATING FUNGI IN AGRICULTURE AND IN GARDENING | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-01-30 | — | — | EP | claimed |
| EP-0062238-A1 | 1,3-Dioxolane derivatives, their preparation, fungicidal agents containing those compounds as active agents and use of such compounds or agents in combating fungi in agriculture and in gardening | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-10-13 | — | — | EP | claimed |
| US-8883786-B2 | Glucocorticoid receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130045972-A1 | GLUCOCORTICOID RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | US | disclosed |
| US-8143280-B2 | Glucocorticoid receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-03-27 | — | — | US | disclosed |
| EP-2205562-B1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-03-16 | — | — | EP | disclosed |
| EP-2205562-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| US-20090088425-A1 | GLUCOCORTICOID RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | US | disclosed |
| WO-2009040288-A1 | 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |
| EP-0385267-A2 | Pyridine derivatives, their preparation and their use as fungicides | CIBA-GEIGY AG (CH) | 1990-09-05 | — | — | EP | disclosed |
| EP-0129507-B1 | MICROBICIDES | CIBA-GEIGY AG (CH) | 1989-02-01 | — | — | EP | disclosed |
| EP-0209854-A2 | Pyridine derivatives and their use as fungicidal agents | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-01-28 | — | — | EP | disclosed |
| EP-0074018-B1 | PYRIDINE AND PYRAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS, FUNGICIDES CONTAINING THESE COMPOUNDS AS ACTIVE SUBSTANCES, USE OF THESE COMPOUNDS OR FUNGICIDES TO COMBAT FUNGI IN AGRICULTURE AND IN HORTICULTURE, AND KETONES AND FUNGICIDES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-09-24 | — | — | EP | disclosed |
| US-4556661-A | FUNGICIDES | HOFFMANN-LA ROCHE INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0062238-B1 | 1,3-DIOXOLANE DERIVATIVES, THEIR PREPARATION, FUNGICIDAL AGENTS CONTAINING THOSE COMPOUNDS AS ACTIVE AGENTS AND USE OF SUCH COMPOUNDS OR AGENTS IN COMBATING FUNGI IN AGRICULTURE AND IN GARDENING | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-01-30 | — | — | EP | disclosed |
| EP-0129507-A2 | Microbicides | CIBA-GEIGY AG (CH) | 1984-12-27 | — | — | EP | disclosed |
| EP-0117485-A2 | Pyridine, pyrazine and pyrimidine derivatives and their use as fungicides | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-09-05 | — | — | EP | disclosed |
| US-4380544-A | 1,3-Dioxolane compounds and their use as fungicides | HOFFMANN-LA ROCHE INC. (US) | 1983-04-19 | — | — | US | disclosed |
| EP-0074018-A2 | Pyridine and pyrazine derivatives, process for the preparation of these compounds, fungicides containing these compounds as active substances, use of these compounds or fungicides to combat fungi in agriculture and in horticulture, and ketones and fungicides containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-03-16 | — | — | EP | disclosed |
| EP-0062238-A1 | 1,3-Dioxolane derivatives, their preparation, fungicidal agents containing those compounds as active agents and use of such compounds or agents in combating fungi in agriculture and in gardening | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088425-A1 | GLUCOCORTICOID RECEPTOR ANTAGONISTS | NR3C1, NR3C2, MC2R | ALDH1A1 1082/4885LMNA 2031/4885GALR3 193/4885 |
| US-20130045972-A1 | GLUCOCORTICOID RECEPTOR ANTAGONISTS | NR3C1, NR3C2, MC2R | ALDH1A1 1082/4885LMNA 2031/4885GALR3 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.