SCHEMBL8404446

SCHEMBL8404446

Cc1ccc(C)c2cnncc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.47
CYP2A6 P11509 3/20 0.40
CCR1 P32246 2/20 0.38
CCR5 P51681 2/20 0.38
CCR8 P51685 2/20 0.38
ALDH1A1 P00352 3/20 0.35
TSHR P16473 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
CYP3A4 P08684 2/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
OPRK1 P41145 1/20 0.34
KMT2A Q03164 1/20 0.34
PSMD14 O00487 1/20 0.33
COPS5 Q92905 1/20 0.33
CASP1 P29466 1/20 0.33
SLC6A2 P23975 1/20 0.33
HTT P42858 1/20 0.33
NOS3 P29474 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24373813 0.84 CYP1A2 (0.36) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL2494204 0.84 CYP1A2 (0.36) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL18630339 0.84 CYP1A2 (0.36) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL19297139 0.81 GPR55 (0.41) CYP1A2SLC6A2
SCHEMBL14599185 0.76 SMN1; SMN2 (0.51) ALDH1A1TSHRTDP1CYP3A4HSD17B10
SCHEMBL8404449 0.75 TSHR (0.50) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL5364164 0.73 ALDH1A1 (0.52) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL10200833 0.72 CCR1 (0.48) CYP1A2CCR1CCR5CCR8ALDH1A1
SCHEMBL812489 0.71 CYP1A2 (0.46) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL12587626 0.71 CCR1 (0.36) CCR1CCR5CCR8NOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023034811-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-03-09 WO disclosed
US-20200332193-A1 LIQUID CRYSTAL ELEMENT USED FOR PHASE CONTROL OF ELECTROMAGNETIC WAVE SIGNAL JNC CORPORATION (JP) 2020-10-22 US disclosed
US-10249830-B2 Carbazole-based compound and organic light-emitting device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2019-04-02 US disclosed
US-20170077419-A1 CARBAZOLE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2017-03-16 US disclosed
EP-2439204-B1 HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER NISSAN CHEMICAL IND LTD (JP) 2017-01-04 EP disclosed
US-9527828-B2 Method for expanding hematopoietic stem cells using heterocyclic compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-12-27 US disclosed
US-9527828-B2 Method for expanding hematopoietic stem cells using heterocyclic compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-12-27 US disclosed
EP-2218716-B1 METHOD FOR AMPLIFYING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND NISSAN CHEMICAL IND LTD (JP) 2016-11-16 EP disclosed
US-9328085-B2 Heterocyclic compounds and expansion agents for hematopoietic stem cells NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-05-03 US disclosed
US-9328085-B2 Heterocyclic compounds and expansion agents for hematopoietic stem cells NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-05-03 US disclosed
US-7297449-B2 Optical recording medium and optical recording apparatus KABUSHIKI KAISHA TOSHIBA (JP) 2007-11-20 US disclosed
US-20070224554-A1 Photothermographic material FUJIFILM CORPORATION (JP) 2007-09-27 US disclosed
US-20070224554-A1 Photothermographic material FUJIFILM CORPORATION (JP) 2007-09-27 US disclosed
US-7223531-B2 Photothermographic material FUJIFILM CORPORATION (JP) 2007-05-29 US disclosed
US-7223531-B2 Photothermographic material FUJIFILM CORPORATION (JP) 2007-05-29 US disclosed
US-20070078137-A1 Method of inhibiting neurotrophin-receptor binding QUEEN'S UNIVERSITY AT KINGSTON (CA) 2007-04-05 US disclosed
US-20070003882-A9 Photothermographic material, and image forming method using same FUKUI KOUTA 2007-01-04 US disclosed
US-20070003882-A9 Photothermographic material, and image forming method using same FUKUI KOUTA 2007-01-04 US disclosed
US-20070003884-A1 Photothermographic material FUJI PHOTO FILM CO., LTD. (JP) 2007-01-04 US disclosed
US-20070003884-A1 Photothermographic material FUJI PHOTO FILM CO., LTD. (JP) 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10249830-B2 Carbazole-based compound and organic light-emitting device including the same OCIAD1, OXA1L, OCIAD2 CYP1A2 42/4885CYP2A6 923/4885CCR1 2037/4885
US-20070078137-A1 Method of inhibiting neurotrophin-receptor binding NGF, NTRK2, BDNF CYP1A2 4634/4885CYP2A6 3775/4885CCR1 1122/4885
US-20170077419-A1 CARBAZOLE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME OCIAD1, OXA1L, CYP1A1 CYP1A2 42/4885CYP2A6 786/4885CCR1 2224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.