Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 9/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408122 | 0.85 | PTGER1 (0.62) | PTGER1RXRACYP1A2FOLH1CCR5 | |
| SCHEMBL8409836 | 0.84 | MRGPRX4 (0.56) | PTGER1RXRAFFAR4ABCB1ABCG2 | |
| SCHEMBL8324067 | 0.83 | ABCB1 (0.53) | PTGER1CYP1A2ABCB1ABCG2FOLH1 | |
| SCHEMBL8321056 | 0.83 | FOLH1 (0.51) | PTGER1CYP1A2FOLH1CCR5 | |
| SCHEMBL9276268 | 0.83 | RXRA (0.47) | PTGER1RXRACYP1A2FFAR4ABCB1 | |
| SCHEMBL8409537 | 0.81 | CCR5 (0.53) | PTGER1CYP1A2ABCB1ABCG2CCR5 | |
| SCHEMBL8324940 | 0.81 | CCR5 (0.53) | PTGER1CYP1A2ABCB1ABCG2CCR5 | |
| SCHEMBL8409884 | 0.81 | RXRA (0.49) | PTGER1RXRAFFAR4FOLH1 | |
| SCHEMBL8406943 | 0.80 | HTR1A (0.65) | PTGER1ABCB1ABCG2CCR5 | |
| SCHEMBL8325136 | 0.78 | ABCB1 (0.51) | PTGER1CYP1A2ABCB1ABCG2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |