Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415265 | 0.89 | PKM (0.56) | KDM4ESMN1; SMN2KMT2AHPGDTSHR | |
| SCHEMBL8520382 | 0.83 | KDM4E (0.58) | MAPTKDM4EKMT2ACYP3A4 | |
| SCHEMBL27616066 | 0.81 | PARP1 (0.51) | PARP1LMNAMAPTKDM4EGAA | |
| SCHEMBL8413952 | 0.79 | GRIA2 (0.53) | LMNAMAPTKDM4EGAAKMT2A | |
| SCHEMBL8413733 | 0.76 | LMNA (0.49) | LMNAMAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL7027741 | 0.76 | KMT2A (0.65) | LMNAMAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL8414072 | 0.74 | MAPT (0.47) | LMNAMAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL8413597 | 0.74 | TSHR (0.46) | LMNAMAPTKDM4EGAAGRIN2D | |
| SCHEMBL8415259 | 0.73 | GRIA2 (0.51) | LMNAMAPTKDM4EKMT2AGRIN2D | |
| SCHEMBL4772036 | 0.70 | KDM4E (0.90) | LMNAMAPTKDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912245-A | AMPA AND KAINATE ANTAGONISTS. | EGIS GYOGYSZERGYAR RT. (HU) | 1999-06-15 | — | — | US | claimed |
| EP-0759910-A1 | ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | EGIS GYOGYSZERGYAR RT. (HU) | 1997-03-05 | — | — | EP | claimed |
| WO-1995031443-A1 | ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | EGIS Gyógyszergyár Rt. (HU) | 1995-11-23 | — | — | WO | claimed |
| US-5912245-A | AMPA AND KAINATE ANTAGONISTS. | EGIS GYOGYSZERGYAR RT. (HU) | 1999-06-15 | — | — | US | disclosed |