Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414459 | 0.85 | NOS3 (0.43) | NOS3NOS1NOS2AAK1PSEN1 | |
| SCHEMBL7405939 | 0.82 | ALDH1A1 (0.45) | AAK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7996806 | 0.79 | SLC6A3 (0.37) | NOS3NOS1NOS2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7402748 | 0.78 | NOS3 (0.42) | NOS3NOS1NOS2AAK1GRN | |
| SCHEMBL18130613 | 0.76 | AAK1 (0.41) | AAK1SMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL13664813 | 0.73 | SMN1; SMN2 (0.69) | AAK1EGFRCTSLCTSBCTSS | |
| SCHEMBL8645241 | 0.72 | BTN3A1 (0.39) | NOS3NOS1NOS2GRNSORT1 | |
| SCHEMBL29462332 | 0.72 | CTSL (0.54) | AAK1CTSLCTSBCTSSCTSK | |
| SCHEMBL22522212 | 0.72 | CTSL (0.54) | AAK1CTSLCTSBCTSSCTSK | |
| SCHEMBL55832 | 0.71 | CTSL (0.60) | AAK1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755405-B1 | PHOSPHONYLDIPEPTIDES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES | ZAMBON SPA (IT) | 1999-08-25 | — | — | EP | disclosed |
| US-5760285-A | METALLOPEPTIDASE INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |