Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CD44 | P16070 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30561864 | 1.00 | CYP3A4 (0.55) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL19738526 | 0.86 | CYP3A4 (0.39) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL272781 | 0.80 | CYP3A4 (0.60) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL30476125 | 0.80 | CYP3A4 (0.60) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL12922668 | 0.79 | CYP3A4 (0.46) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL16341038 | 0.79 | CYP3A4 (0.40) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL405019 | 0.79 | CYP3A4 (0.40) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL7532704 | 0.79 | TSHR (0.43) | CYP3A4TSHRMAPK1ALDH1A1TDP1 | |
| SCHEMBL21937810 | 0.79 | CYP3A4 (0.40) | CYP3A4TSHRMAPK1CD44ALDH1A1 | |
| SCHEMBL405877 | 0.79 | CD44 (0.65) | CYP3A4TSHRMAPK1CD44ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL MED MOUNT SINAI (US) | 2024-01-25 | — | — | US | disclosed |
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL MED MOUNT SINAI (US) | 2024-01-25 | — | — | US | disclosed |
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL MED MOUNT SINAI (US) | 2024-01-25 | — | — | US | disclosed |
| CN-116836130-B | Synthesis method of 3, 4-dihydrobenzothiadiazine compound | 嘉实（湖南）医药科技有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-116836130-A | Synthesis method of 3, 4-dihydrobenzothiadiazine compound | 嘉实（湖南）医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| WO-2022104070-A2 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-05-19 | — | — | WO | disclosed |
| WO-2022104070-A2 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-05-19 | — | — | WO | disclosed |
| EP-3569606-B1 | METAL COMPLEXES OF CYCLOMETALLATED IMIDAZO (1,2-F)PHENANTHRIDINE AND DIIMIDAZO (1,2-A; 1', 2'-C)QUINAZOLINE LIGANDS AND ISOELECTRONIC AND BENZANNULATED ANALOGS THEREOF | UNIVERSAL DISPLAY CORP (US) | 2022-01-05 | — | — | EP | disclosed |
| US-20080297033-A1 | BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS | UNIVERSAL DISPLAY CORPORATION | 2008-12-04 | — | — | US | disclosed |
| US-20080297033-A1 | BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS | UNIVERSAL DISPLAY CORPORATION | 2008-12-04 | — | — | US | disclosed |
| US-20080297033-A1 | BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS | UNIVERSAL DISPLAY CORPORATION | 2008-12-04 | — | — | US | disclosed |
| EP-1981898-A2 | METAL COMPLEXES OF CYCLOMETALLATED IMIDAZOÝ1,2-f¨PHENANTHRIDINE AND DIIMIDAZOÝ1,2-A:1',2'-C¨QUINAZOLINE LIGANDS AND ISOELECTRONIC AND BENZANNULATED ANALOGS THEREOF | Universal Display Corporation (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20080064733-A1 | Small Molecule Inhibition of Pdz-Domain Interaction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-03-13 | — | — | US | disclosed |
| US-20080021082-A1 | Small molecule inhibition of a PDZ-domain interaction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-01-24 | — | — | US | disclosed |
| WO-2007095118-A2 | METAL COMPLEXES OF CYCLOMETALLATED IMIDAZO[1,2-f]PHENANTHRIDINE AND DIIMIDAZO[1,2-A:1',2'-C]QUINAZOLINE LIGANDS AND ISOELECTRONIC AND BENZANNULATED ANALOGS THEREOF | UNIVERSAL DISPLAY CORPORATION (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070190359-A1 | Metal complexes of cyclometallated imidazo[1,2-ƒ]phenanthridine and diimidazo[1,2-a:1',2'-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof | UNIVERSAL DISPLAY CORPORATION | 2007-08-16 | — | — | US | disclosed |
| US-20070190359-A1 | Metal complexes of cyclometallated imidazo[1,2-ƒ]phenanthridine and diimidazo[1,2-a:1',2'-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof | UNIVERSAL DISPLAY CORPORATION | 2007-08-16 | — | — | US | disclosed |
| US-20070190359-A1 | Metal complexes of cyclometallated imidazo[1,2-ƒ]phenanthridine and diimidazo[1,2-a:1',2'-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof | UNIVERSAL DISPLAY CORPORATION | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | CYP3A4 2539/4885TSHR 4576/4885MAPK1 1468/4885 |
| US-20080064733-A1 | Small Molecule Inhibition of Pdz-Domain Interaction | DVL1, DVL3, PDLIM5 | CYP3A4 4870/4885TSHR 4601/4885MAPK1 1036/4885 |
| US-20240025868-A1 | PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AGE-RELATED AND NEUROLOGICAL DISEASES | ACE2, BACE2, PSEN2 | CYP3A4 757/4885TSHR 4426/4885MAPK1 1577/4885 |
| US-20080021082-A1 | Small molecule inhibition of a PDZ-domain interaction | DVL1, DVL3, PDLIM5 | CYP3A4 4852/4885TSHR 4482/4885MAPK1 1070/4885 |
| US-20080297033-A1 | BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS | IK, CRY1, MAP1LC3C | CYP3A4 1210/4885TSHR 4444/4885MAPK1 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.