Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3619365 | 0.87 | MAPK1 (0.61) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL8228750 | 0.85 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL31008799 | 0.83 | CYP1A2 (0.58) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL14259848 | 0.83 | POLB (0.56) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL17263078 | 0.76 | ACSS2 (0.56) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| Dimethylamine SCHEMBL6930444 | 0.74 | KDM4E (0.92) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL2719218 | 0.74 | NPC1 (0.67) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL12397237 | 0.73 | HTT (0.62) | ALDH1A1SMN1; SMN2KDM4ENPSR1RAB9A | |
| SCHEMBL18324322 | 0.73 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2RECQLKDM4ENPSR1 | |
| SCHEMBL9302226 | 0.73 | HDAC1 (0.73) | ALDH1A1SMN1; SMN2RECQLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144591-A1 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | SCHERING CORPORATION | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | CNR2, GPR119, GLP1R | ALDH1A1 3184/4885SMN1; SMN2 4298/4885RECQL 3953/4885 |
| US-20100144591-A1 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GK, GCK | ALDH1A1 612/4885SMN1; SMN2 1534/4885RECQL 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.