Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422340 | 0.87 | MEN1 (0.35) | HSD17B10POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL7824393 | 0.70 | MAPT (0.46) | HSD17B10POLBKDM4ETSHRHTT | |
| SCHEMBL8420334 | 0.68 | TGFBR1 (0.32) | HSD17B10KDM4EGAAMAPTMEN1 | |
| SCHEMBL7817035 | 0.68 | F2 (0.47) | HSD17B10POLBKDM4ETSHRADORA2A | |
| SCHEMBL11744707 | 0.66 | HSD17B10 (0.70) | HSD17B10POLBKDM4ETSHRMAPK1 | |
| SCHEMBL7555716 | 0.66 | CYP1A2 (0.43) | HSD17B10POLBKDM4ETSHRMAPK1 | |
| SCHEMBL4991673 | 0.64 | SMN1; SMN2 (0.73) | HSD17B10MAPK1TDP1GAALMNA | |
| SCHEMBL7410059 | 0.63 | CYP2D6 (0.39) | HSD17B10POLBKDM4ETSHRMAPK1 | |
| SCHEMBL7809247 | 0.63 | F2 (0.47) | POLBKDM4EHTTL3MBTL1MAPT | |
| SCHEMBL4741336 | 0.62 | LMNA (0.57) | KDM4ETDP1HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |