SCHEMBL8423316

SCHEMBL8423316

Cc1cn(-c2cc(Cl)cc(Cl)c2)c(=NC(=O)C(F)F)s1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.34
POLB P06746 1/20 0.34
NPSR1 Q6W5P4 1/20 0.30
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8423732 0.91 USP2 (0.34) USP2POLBNPSR1
SCHEMBL8428041 0.88 USP2 (0.33) USP2POLB
SCHEMBL8424264 0.87 GABRA2 (0.35) USP2POLBNOTUM
SCHEMBL8428099 0.86 USP2 (0.33) USP2POLB
SCHEMBL2862916 0.80 ALDH1A1 (0.40) NPSR1NOTUM
SCHEMBL2862920 0.80 ALDH1A1 (0.40) NPSR1NOTUM
SCHEMBL8428107 0.79 PKM (0.37) POLBNOTUM
SCHEMBL8424212 0.78 AR (0.37) USP2POLBNOTUM
SCHEMBL8425430 0.78 NPC1 (0.42) NPSR1
SCHEMBL8424639 0.77 GABRA2 (0.34) NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed