Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437857 | 0.81 | PTGS2 (0.39) | KDM4EHSD17B10POLBGSK3BGSK3A | |
| SCHEMBL8434025 | 0.79 | PTGS2 (0.48) | KDM4EGSK3BMAPTKMT2AMEN1 | |
| SCHEMBL8520543 | 0.73 | CYP3A4 (0.48) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL13730605 | 0.66 | KDM4E (0.50) | KDM4EALOX15MAPK1CASP1HSD17B10 | |
| SCHEMBL8433530 | 0.65 | ALDH1A1 (0.33) | KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2446004 | 0.62 | GSK3B (0.48) | KDM4EPOLBGSK3BGSK3AF2 | |
| SCHEMBL28475407 | 0.62 | — | — | |
| SCHEMBL14257142 | 0.60 | LGMN (0.43) | KDM4EALOX15MAPK1CASP1HSD17B10 | |
| SCHEMBL15910085 | 0.60 | TDP2 (0.32) | — | |
| SCHEMBL30433929 | 0.60 | TDP2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889185-A | Method of synthesizing isoindolequinones and derivatives thereof | THE UNIVERSITY OF AKRON (US) | 1999-03-30 | — | — | US | disclosed |
| WO-1998046567-A1 | METHOD OF SYNTHESIZING ISOINDOLEQUINONES AND DERIVATIVES THEREOF | THE UNIVERSITY OF AKRON (US) | 1998-10-22 | — | — | WO | disclosed |