Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447090 | 0.88 | OPRD1 (0.56) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL27472889 | 0.84 | OPRD1 (0.57) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL7466581 | 0.81 | TSHR (0.53) | SMN1; SMN2LMNAOPRD1OPRK1KMT2A | |
| SCHEMBL9037444 | 0.79 | OPRD1 (0.51) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL6248104 | 0.79 | KMT2A (0.54) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL8915729 | 0.77 | OPRM1 (0.53) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| SCHEMBL27381366 | 0.76 | KMT2A (0.65) | OPRD1OPRK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL16244835 | 0.75 | OPRD1 (0.57) | SMN1; SMN2LMNAPOLBOPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL8635061 | 0.75 | KMT2A (0.63) | OPRD1OPRK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL533646 | 0.75 | POLB (0.97) | SMN1; SMN2LMNAPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946548-A1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027086-A1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1998-06-25 | — | — | WO | disclosed |