Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TET3 | O43151 | 2/20 | 0.46 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.46 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.46 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.46 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447090 | 0.89 | OPRD1 (0.56) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL6248104 | 0.86 | KMT2A (0.54) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL8915729 | 0.80 | OPRM1 (0.53) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL27472889 | 0.80 | OPRD1 (0.57) | OPRD1OPRK1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL8438413 | 0.79 | SMN1; SMN2 (0.55) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL8352820 | 0.78 | TSHR (0.53) | OPRD1OPRK1KMT2ATET3FBXL19 | |
| SCHEMBL30659245 | 0.74 | SMN1; SMN2 (0.56) | OPRD1OPRK1KMT2AMEN1LMNA | |
| SCHEMBL346648 | 0.74 | SMN1; SMN2 (0.56) | OPRD1OPRK1KMT2AMEN1LMNA | |
| SCHEMBL30297575 | 0.74 | CYP3A4 (0.62) | KMT2AMEN1SMN1; SMN2TSHRITGB3 | |
| SCHEMBL27942388 | 0.73 | OPRM1 (0.49) | OPRD1OPRK1KMT2AMEN1TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696280-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMA (US) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994026735-A1 | SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-24 | — | — | WO | disclosed |