Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772454 | 0.85 | POLB (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8438916 | 0.83 | PLAAT3 (0.45) | ALDH1A1TP53MEN1KMT2APOLB | |
| SCHEMBL8772476 | 0.81 | ALDH1A1 (0.46) | KCNH2ALDH1A1POLBSIGMAR1TDP1 | |
| SCHEMBL8439355 | 0.77 | GSK3A (0.44) | ALDH1A1TP53GAAMEN1KMT2A | |
| SCHEMBL8104154 | 0.76 | FAAH (0.44) | HTR2AKCNH2TP53MEN1KMT2A | |
| SCHEMBL8772537 | 0.74 | POLB (0.40) | ALDH1A1POLBCCR3SIGMAR1GSK3A | |
| SCHEMBL8772474 | 0.74 | POLB (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8772449 | 0.74 | CYP1A2 (0.42) | HTR2AALDH1A1FKBP1ATP53GAA | |
| SCHEMBL8439468 | 0.72 | HTR2A (0.40) | HTR2AKCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL8441542 | 0.71 | ALDH1A1 (0.52) | KCNH2ALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |