Sugi Predict

Sugi Predict / Compounds / SCHEMBL844273

SCHEMBL844273

SCHEMBL844273

O=Cc1cnccc1C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ERN1 O75460 4/20 0.48
▸ NFE2L2 Q16236 1/20 0.39
▸ NPC1 O15118 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ GAA P10253 1/20 0.36
▸ CCNT1 O60563 1/20 0.35
▸ CDK9 P50750 1/20 0.35
▸ HASPIN Q8TF76 1/20 0.35
▸ SLC22A12 Q96S37 1/20 0.35
▸ NFKB1 P19838 1/20 0.34
▸ CYP2A6 P11509 2/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ KIF11 P52732 1/20 0.33
▸ KDM5A P29375 1/20 0.33
▸ KDM4C Q9H3R0 1/20 0.33
▸ CYP11B1 P15538 1/20 0.33
▸ CYP11B2 P19099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30149259 1.00 ERN1 (0.48) ERN1NFE2L2NPC1POLBGAA
SCHEMBL30800801 0.84 ERN1 (0.48) ERN1NFE2L2NPC1POLBGAA
SCHEMBL9274800 0.84 ERN1 (0.48) ERN1NFE2L2NPC1POLBGAA
SCHEMBL25398893 0.80 NFE2L2 (0.39) ERN1NFE2L2NPC1POLBGAA
SCHEMBL13126151 0.80 ALOX5 (0.36) ERN1NFE2L2CCNT1CDK9HASPIN
SCHEMBL3663643 0.80 NFE2L2 (0.36) ERN1NFE2L2NPC1POLBGAA
SCHEMBL16446421 0.77 NFE2L2 (0.40) ERN1NFE2L2NPC1POLBGAA
SCHEMBL14686341 0.77 NFE2L2 (0.46) ERN1NFE2L2NPC1POLBSLC22A12
SCHEMBL29988644 0.75 NFE2L2 (0.40) ERN1NFE2L2NPC1POLBGAA
SCHEMBL20772453 0.73 KIF11 (0.41) NPC1POLBGAASLC22A12L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115747298-A Insect nicotinamide enzyme inhibitor and identification method and application of insect nicotinamide enzyme inhibitor to pesticide 浙江大学 2023-03-07 — — CN claimed
CN-110669107-A Antibacterial peptide and preparation method thereof 上海医药工业研究院 2020-01-10 — — CN claimed
EP-1507761-B1 PYRIDINE CARBOXAMIDE DERIVATIVES AND THEIR USE AS PESTICIDES MERIAL INC (US) 2016-02-24 — — EP claimed
EP-2275412-A1 Indole and benzimidazole derivatives Novartis Vaccines and Diagnostics, Inc. (US) 2011-01-19 — — EP claimed
US-7608723-B2 N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2009-10-27 — — US claimed
US-20080317744-A1 Indole and Benzimidazole Derivatives CHIRON CORPORATION (US) 2008-12-25 — — US claimed
CN-100425609-C N-Heteroaryl Nicotinamide Derivatives SANKYO AGRO CO LTD (JP) 2008-10-15 — — CN claimed
EP-1807399-A2 INDOLE AND BENZIMIDAZOLE DERIVATIVES Novartis Vaccines and Diagnostics, Inc. (US) 2007-07-18 — — EP claimed
WO-2006049835-A2 INDOLE AND BENZIMIDAZOLE DERIVATIVES NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) 2006-05-11 — — WO claimed
US-20060084687-A1 Indole and benzimidazole derivatives NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2006-04-20 — — US claimed
US-20250262205-A1 DUAL MAGL AND FAAH INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2025-08-21 — — US disclosed
US-12318383-B2 Dual MAGL and FAAH inhibitors LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2025-06-03 — — US disclosed
EP-4496570-A2 SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS The Scripps Research Institute (US) 2025-01-29 — — EP disclosed
EP-4424683-A2 DUAL MAGL AND FAAH INHIBITORS Lundbeck La Jolla Research Center, Inc. (US) 2024-09-04 — — EP disclosed
EP-3595665-B1 DUAL MAGL AND FAAH INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER INC (US) 2024-08-28 — — EP disclosed
WO-2004033427-A1 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS 11-BETAHSD1 INHIBITORS ASTRAZENECA AB (SE) 2004-04-22 — — WO disclosed
EP-0828739-B1 BICYCLIC AMINES AS INSECTICIDES SYNGENTA LTD (GB) 2002-09-11 — — EP disclosed
CN-1365357-A Trifluoromethyl pyri(mi) diene carboxamides SYNGENTA PARTICIPATIONS AG (CH) 2002-08-21 — — CN disclosed
CN-1044233-C Amide compounds and their salts, processes for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA (JP) 1999-07-21 — — CN disclosed
CN-1081670-A Amide compound and salt thereof, their manufacturing process and pesticide composition thereof ISHIHARA SANGYO KAISHA (JP) 1994-02-09 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262205-A1 DUAL MAGL AND FAAH INHIBITORS FAAH, FAAH2, MAG ERN1 3423/4885NFE2L2 2551/4885NPC1 1227/4885
US-12318383-B2 Dual MAGL and FAAH inhibitors FAAH, FAAH2, MAG ERN1 3423/4885NFE2L2 2551/4885NPC1 1227/4885
US-20060084687-A1 Indole and benzimidazole derivatives IDO1, IDO2, AADAC ERN1 4484/4885NFE2L2 1884/4885NPC1 832/4885
US-20080317744-A1 Indole and Benzimidazole Derivatives IDO1, IDO2, AADAC ERN1 4484/4885NFE2L2 1884/4885NPC1 832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.