SCHEMBL8444568

SCHEMBL8444568

C=CCN(Oc1ccccc1)c1ncccn1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
BCHE P06276 3/20 0.36
ALDH1A1 P00352 3/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
ATM Q13315 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
MAPT P10636 1/20 0.35
TSHR P16473 1/20 0.33
THRB P10828 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
KCNA3 P22001 1/20 0.32
LSS P48449 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10378711 0.85 SMN1; SMN2 (0.39) KDM4EKMT2AMEN1SMN1; SMN2BCHE
SCHEMBL9772660 0.80 KDM4E (0.41) KDM4EKMT2AMEN1SMN1; SMN2BCHE
SCHEMBL6262251 0.79 ALDH1A1 (0.39) KDM4EKMT2AMEN1SMN1; SMN2BCHE
SCHEMBL9507354 0.74 KDM4E (0.45) KDM4EKMT2AMEN1SMN1; SMN2BCHE
SCHEMBL8015667 0.71 MAPT (0.44) KDM4EKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL11076565 0.68 KDM4E (0.45) KDM4EKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL29113998 0.68 KDM4E (0.41) KDM4EKMT2AMEN1SMN1; SMN2BCHE
SCHEMBL19610489 0.67 KDM4E (0.58) KDM4EKMT2AMEN1SMN1; SMN2BCHE
SCHEMBL7116438 0.67 KDM4E (0.50) KDM4EKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL3261534 0.66 CRHR1 (0.36) KDM4EKMT2AMEN1SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0555388-B1 INSECTICIDAL, ACARICIDAL AND FUNGICIDAL AMINOPYRIMIDINES DU PONT (US) 1999-01-27 EP disclosed
US-5703064-A MIXTURE OF PYRIMIDIFEN WITH QUINALPHOS SANKYO COMPANY, LIMITED (JP) 1997-12-30 US disclosed
EP-0672348-A1 Pesticidal combinations SANKYO COMPANY LIMITED (JP) 1995-09-20 EP disclosed
US-5378708-A Agricultural pesticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-01-03 US disclosed
EP-0357348-B1 Process for preparing p-bromophenoxyacetaldehyde dialkylacetal derivatives UBE INDUSTRIES (JP) 1994-06-08 EP disclosed
EP-0555388-A1 INSECTICIDAL, ACARICIDAL AND FUNGICIDAL AMINOPYRIMIDINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-08-18 EP disclosed
WO-1992008704-A1 INSECTICIDAL, ACARICIDAL AND FUNGICIDAL AMINOPYRIMIDINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-05-29 WO disclosed
US-4982008-A Process for preparing p-bromophenoxyacetaldehyde dialkylacetal compounds UBE INDUSTRIES, LTD. (JP) 1991-01-01 US disclosed
EP-0196524-B1 PHENOXYALKYLAMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND INSECTICIDAL AND ACARICIDAL COMPOSITIONS CONTAINING THEM SANKYO COMPANY LIMITED (JP) 1990-03-07 EP disclosed
EP-0357348-A2 Process for preparing p-bromophenoxyacetaldehyde dialkylacetal derivatives UBE INDUSTRIES, LTD. (JP) 1990-03-07 EP disclosed
US-4845097-A AGRICULTURE SANKYO COMPANY LIMITED (JP) 1989-07-04 US disclosed
US-4845097-A AGRICULTURE SANKYO COMPANY LIMITED (JP) 1989-07-04 US disclosed
EP-0196524-A2 Phenoxyalkylaminopyrimidine derivatives, their preparation and insecticidal and acaricidal compositions containing them SANKYO COMPANY LIMITED (JP) 1986-10-08 EP disclosed
EP-0196524-A2 Phenoxyalkylaminopyrimidine derivatives, their preparation and insecticidal and acaricidal compositions containing them SANKYO COMPANY LIMITED (JP) 1986-10-08 EP disclosed