Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 7/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445581 | 0.82 | DRD2 (0.65) | DRD2DRD4HTR1AKDM4EALDH1A1 | |
| SCHEMBL5656389 | 0.82 | ADRA1D (0.65) | ADRA1ADRD2HTR1A | |
| SCHEMBL28729033 | 0.81 | KDM4E (0.65) | DRD3DRD2DRD4HTR1AKDM4E | |
| SCHEMBL10365793 | 0.81 | DRD2 (0.61) | DRD3DRD2DRD4HTR1AKDM4E | |
| SCHEMBL8444161 | 0.79 | DRD2 (0.62) | DRD3DRD2DRD4HTR1AKDM4E | |
| SCHEMBL8442303 | 0.78 | HTR1A (0.74) | DRD3ADRA1ADRD2DRD4HTR1A | |
| SCHEMBL5656677 | 0.78 | ADRA1D (0.60) | ADRA1ADRD2HTR1AKDM4EALDH1A1 | |
| SCHEMBL1387947 | 0.77 | ADRA1D (0.64) | ADRA1ADRD2HTR1AKDM4EALDH1A1 | |
| SCHEMBL26238797 | 0.77 | DRD2 (0.54) | DRD3ADRA1ADRD2DRD4HTR1A | |
| SCHEMBL5655841 | 0.76 | ADRA1A (0.71) | DRD3ADRA1ADRD2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955296-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-10 | — | — | EP | claimed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | claimed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | claimed |