Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749382 | 0.86 | SLC6A4 (0.35) | CASP1HSD17B10TSHRSLC6A2SLC6A4 | |
| SCHEMBL16691418 | 0.77 | L3MBTL1 (0.41) | CASP1HSD17B10TSHR | |
| SCHEMBL8445608 | 0.74 | TSHR (0.40) | CASP1HSD17B10TSHRARKIF11 | |
| SCHEMBL11536457 | 0.72 | CASP1 (0.37) | CASP1HSD17B10TSHRSLC6A2SLC6A4 | |
| SCHEMBL7752071 | 0.72 | CASP1 (0.35) | CASP1HSD17B10TSHRSLC6A2SLC6A4 | |
| SCHEMBL6139367 | 0.71 | TSHR (0.38) | CASP1HSD17B10TSHRKIF11 | |
| SCHEMBL7750623 | 0.71 | SMN1; SMN2 (0.39) | CASP1HSD17B10TSHRSLC6A2SLC6A4 | |
| SCHEMBL3519610 | 0.70 | L3MBTL1 (0.45) | CASP1HSD17B10TSHR | |
| SCHEMBL7749385 | 0.69 | KIF11 (0.38) | CASP1HSD17B10TSHRKIF11 | |
| SCHEMBL5879396 | 0.69 | SIGMAR1 (0.36) | CASP1HSD17B10TSHRKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888304-A1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI (FR) | 1999-01-07 | — | — | EP | claimed |
| WO-1997032852-A1 | SUBSTITUTED 3-ARYL-3-CARBOXYALKYL GLUTARAMIDES, METHOD FOR PREPARING SAME BY 4-ARYLO-4-CYANOHEPTANE DICARBOXYLIC ACID CYCLISATION, AND USE THEREOF FOR PREPARING 3-ARYL-3-HYDROXYALKYLPIPERIDINES | SANOFI (FR) | 1997-09-12 | — | — | WO | claimed |