Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | HTR1D | P28221 | 4/20 | 0.52 |
| ▸ | HTR1B | P28222 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 7/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503776 | 0.81 | HTR1D (0.77) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL9006903 | 0.78 | HTR1D (0.54) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL7373245 | 0.73 | HTR2A (0.54) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL7291348 | 0.72 | HTR1A (0.46) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL19506591 | 0.71 | GABRA1 (0.51) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL11924849 | 0.71 | CSNK2A1 (0.54) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL17440159 | 0.71 | TRPA1 (0.48) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL4512060 | 0.69 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL9001660 | 0.69 | KIF11 (0.49) | HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL11924512 | 0.69 | HTR1A (0.51) | HTR1AHTR1DHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991645-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000381-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 1999-01-07 | — | — | WO | disclosed |