SCHEMBL8446487

SCHEMBL8446487

C[Si](C)(C)Oc1ccncc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.38
MAPT P10636 2/20 0.38
SMN1; SMN2 Q16637 5/20 0.37
CYP2D6 P10635 4/20 0.37
CYP1A2 P05177 4/20 0.37
CYP3A4 P08684 4/20 0.37
CYP2C19 P33261 4/20 0.37
KDM4E B2RXH2 3/20 0.37
NPC1 O15118 3/20 0.37
CYP2C9 P11712 3/20 0.37
RAB9A P51151 3/20 0.37
HPGD P15428 2/20 0.37
CHRM5 P08912 1/20 0.36
CHKA P35790 1/20 0.36
USP2 O75604 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
ALDH1A1 P00352 2/20 0.35
HDAC8 Q9BY41 1/20 0.35
CHRM1 P11229 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4763549 0.82 CA1 (0.39) MEN1KMT2AALDH1A1MAPK1
SCHEMBL19953130 0.77 LMNA (0.42) LMNAMAPTSMN1; SMN2CYP2D6CYP1A2
SCHEMBL5482305 0.75 PREP (0.44) LMNAMAPTSMN1; SMN2CYP2D6CYP1A2
SCHEMBL9714337 0.74 ESR2 (0.39) MAPTSMN1; SMN2CYP2D6CYP3A4KDM4E
SCHEMBL9115160 0.74 ALDH1A1 (0.41) LMNAMAPTSMN1; SMN2CYP3A4NPC1
SCHEMBL17881929 0.74 ESR2 (0.39) MAPTSMN1; SMN2CYP2D6CYP3A4KDM4E
SCHEMBL232678 0.74 CA4 (0.48) LMNAMAPTKDM4ENPC1RAB9A
SCHEMBL2016960 0.72 ACHE (0.50) LMNAMAPTSMN1; SMN2CYP3A4NPC1
Ammonia Solution, Strong SCHEMBL28447150 0.72 CA4 (0.46) LMNAMAPTKDM4ENPC1RAB9A
SCHEMBL11233031 0.72 CA1 (0.61) MAPTCYP1A2CYP3A4KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119118916-A Preparation method of 4-dimethylaminopyridine and catalyst thereof 湖南斯派克科技股份有限公司 2024-12-13 CN disclosed
EP-0699666-B1 Heterocyclic substituted benzoylguanidine MERCK PATENT GMBH (DE) 1999-01-07 EP disclosed
US-5753680-A Heterocyclyl-benzoylguanidines MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-05-19 US disclosed
EP-0699666-A1 Heterocyclic substituted benzoylguanidine MERCK PATENT GmbH (DE) 1996-03-06 EP disclosed
US-4855420-A Cephalosporin derivatives ICI PHARMA (FR) 1989-08-08 US disclosed
US-4690784-A Process for preparing phosphatidylcholine derivatives NIPPON FINE CHEMICAL CO., LTD. (JP) 1987-09-01 US disclosed
US-4678781-A BACTERICIDAL ANTIBIOTICS ICI PHARMA (FR) 1987-07-07 US disclosed
US-4119775-A ANTIBACTERIAL RICHARDSON-MERRELL INC. (US) 1978-10-10 US disclosed
US-3989687-A ANTIBACTERIAL RICHARDSON-MERRELL INC. (US) 1976-11-02 US disclosed