SCHEMBL8447346

SCHEMBL8447346

BrCc1cc(Br)cc(CI)c1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.33
TRPA1 O75762 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29482737 0.89 TRPA1 (0.36) TRPA1ALDH1A1TSHR
SCHEMBL29482738 0.89 TRPA1 (0.36) TRPA1ALDH1A1TSHR
SCHEMBL642402 0.87 IDO1 (0.40) IDO1TRPA1ALDH1A1TSHR
SCHEMBL22110461 0.84 IDO1 (0.44) IDO1TSHR
SCHEMBL400236 0.81 IDO1 (0.46) IDO1TRPA1ALDH1A1TSHR
SCHEMBL24150147 0.78 ACHE (0.39)
SCHEMBL13973047 0.75 ACHE (0.40) IDO1TRPA1ALDH1A1TSHR
SCHEMBL331501 0.74 TRPA1 (0.47) TRPA1ALDH1A1TSHR
SCHEMBL5442950 0.74 ALDH1A1 (0.30) ALDH1A1
SCHEMBL28056120 0.73 TACR1 (0.40) IDO1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5877214-A Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis MERCK & CO., INC. (US) 1999-03-02 US disclosed