Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355993 | 0.78 | HTR6 (0.47) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL673623 | 0.73 | LMNA (0.61) | TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL672047 | 0.73 | LMNA (0.61) | TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL9272779 | 0.73 | HTR6 (0.52) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL825414 | 0.72 | LMNA (0.63) | TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL7337536 | 0.71 | NPC1 (0.47) | TSHRSIGMAR1 | |
| SCHEMBL30872535 | 0.70 | ALDH1A1 (0.57) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8718249 | 0.70 | LMNA (0.61) | TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL638764 | 0.70 | LMNA (0.61) | TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL149160 | 0.70 | LMNA (0.61) | TSHRKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999000669-A1 | NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1999-01-07 | — | — | WO | disclosed |