Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845048 | 0.93 | DGAT1 (0.50) | DGAT1SMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL845255 | 0.86 | CYP2C9 (0.47) | ALDH1A1NPC1CYP2C9CYP2C19TSHR | |
| SCHEMBL845250 | 0.84 | HCRTR1 (0.46) | DGAT1SMN1; SMN2KDM4EALDH1A1CYP2C9 | |
| SCHEMBL845935 | 0.84 | PABPC1 (0.44) | DGAT1SMN1; SMN2KDM4EALDH1A1CYP2C9 | |
| SCHEMBL845405 | 0.83 | TRPV1 (0.46) | DGAT1SMN1; SMN2KDM4ENPC1CYP2C9 | |
| SCHEMBL845234 | 0.83 | RHOC (0.43) | SMN1; SMN2ALDH1A1RAB9ANPC1CYP2C9 | |
| SCHEMBL845643 | 0.83 | MAPK1 (0.50) | DGAT1ALDH1A1RAB9ACYP2C9CYP2C19 | |
| SCHEMBL844884 | 0.82 | HTT (0.48) | ALDH1A1NPC1CYP2C9CYP2C19TSHR | |
| SCHEMBL13272265 | 0.80 | DGAT1 (0.41) | DGAT1SMN1; SMN2KDM4EALDH1A1CYP2C9 | |
| SCHEMBL845686 | 0.79 | HSD11B1 (0.43) | DGAT1SMN1; SMN2ALDH1A1RAB9ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |