Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871971 | 0.92 | PDE5A (0.42) | GAAPDE5APABPC1LMNAKDM4E | |
| SCHEMBL845060 | 0.87 | KDM4E (0.51) | GAAPABPC1LMNAKDM4ECYP2C9 | |
| SCHEMBL845518 | 0.86 | GAA (0.52) | GAAPDE5APABPC1LMNAKDM4E | |
| SCHEMBL845697 | 0.84 | ALDH1A1 (0.45) | PABPC1MAPK1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL845433 | 0.83 | PABPC1 (0.42) | GAAPABPC1LMNAKDM4EMAPK1 | |
| SCHEMBL845442 | 0.83 | CYP2C9 (0.43) | PABPC1MAPK1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL845301 | 0.80 | PABPC1 (0.51) | GAAPABPC1LMNAKDM4EMAPK1 | |
| SCHEMBL873781 | 0.80 | KDM4E (0.44) | GAAPABPC1LMNAKDM4ECYP2C9 | |
| SCHEMBL13272511 | 0.80 | KDM4E (0.43) | GAAPABPC1LMNAKDM4ECYP2C9 | |
| SCHEMBL13272509 | 0.80 | TRPV1 (0.45) | PABPC1LMNAKDM4EMAPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |