Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.37 |
| ▸ | PFKFB2 | O60825 | 3/20 | 0.37 |
| ▸ | PFKFB1 | P16118 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845330 | 0.92 | GAA (0.47) | PDE5AGAAPABPC1LMNAKDM4E | |
| SCHEMBL872415 | 0.86 | PABPC1 (0.38) | GAAPABPC1LMNAKDM4EMAPK1 | |
| SCHEMBL871771 | 0.83 | PABPC1 (0.44) | GAAPABPC1LMNAKDM4EMAPK1 | |
| SCHEMBL872930 | 0.82 | GAA (0.52) | GAAPABPC1LMNAKDM4EMAPK1 | |
| SCHEMBL10119551 | 0.82 | DHODH (0.40) | GAASCN9ASCN3ASCN5ACYP2C9 | |
| SCHEMBL10119636 | 0.81 | CYP2C9 (0.38) | PABPC1MAPK1SCN9ASCN3APFKFB3 | |
| SCHEMBL10119347 | 0.81 | ALDH1A1 (0.43) | GAASCN9ASCN3APFKFB3PFKFB2 | |
| SCHEMBL10119513 | 0.80 | JAK2 (0.41) | SCN9ASCN3ASCN5ACYP2C9CYP2C19 | |
| SCHEMBL845060 | 0.80 | KDM4E (0.51) | GAAPABPC1HSD17B10LMNAKDM4E | |
| SCHEMBL845518 | 0.80 | GAA (0.52) | PDE5AGAAPABPC1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |