Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845060 | 0.92 | KDM4E (0.51) | KDM4ELMNAHSD17B10KDM1ARCOR1 | |
| SCHEMBL10119341 | 0.82 | LMNA (0.38) | KDM4ELMNAHSD17B10APPNPSR1 | |
| SCHEMBL845005 | 0.81 | KDM4E (0.54) | KDM4ELMNAHSD17B10KDM1ARCOR1 | |
| SCHEMBL845330 | 0.80 | GAA (0.47) | KDM4ELMNATSHRL3MBTL1ALDH1A1 | |
| SCHEMBL13272511 | 0.80 | KDM4E (0.43) | KDM4ELMNAHSD17B10KDM1ARCOR1 | |
| SCHEMBL845841 | 0.76 | TRPV1 (0.45) | KDM4ELMNAALDH1A1PABPC1CYP2C9 | |
| SCHEMBL13272509 | 0.76 | TRPV1 (0.45) | KDM4ELMNAALDH1A1PABPC1CYP2C9 | |
| SCHEMBL845442 | 0.76 | CYP2C9 (0.43) | ALDH1A1PABPC1CYP2C9CYP2C19 | |
| SCHEMBL845353 | 0.76 | KDM4E (0.52) | KDM4ELMNAHSD17B10KDM1ARCOR1 | |
| SCHEMBL845697 | 0.75 | ALDH1A1 (0.45) | NPSR1TSHRALDH1A1PABPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |