Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872515 | 0.91 | PIK3CA (0.33) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL845096 | 0.85 | TP53 (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL845439 | 0.83 | ALDH1A1 (0.38) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL873619 | 0.81 | TP53 (0.34) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL845429 | 0.80 | CTSS (0.44) | MCHR1MEN1KMT2APOLBNAMPT | |
| SCHEMBL845131 | 0.80 | PABPC1 (0.49) | MEN1KMT2APABPC1 | |
| SCHEMBL845007 | 0.80 | PABPC1 (0.49) | MEN1KMT2APABPC1 | |
| SCHEMBL872636 | 0.79 | POLB (0.33) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL845354 | 0.78 | POLB (0.57) | MEN1KMT2APOLB | |
| SCHEMBL13272255 | 0.77 | ALDH1A1 (0.33) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |