Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.30 |
| ▸ | MTOR | P42345 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PNLIP | P16233 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873764 | 0.92 | TP53 (0.35) | TP53HCRTR1HCRTR2THRB | |
| SCHEMBL845096 | 0.91 | TP53 (0.40) | TP53ALDH1A1MCL1GAATHRB | |
| SCHEMBL872515 | 0.87 | PIK3CA (0.33) | THRBPIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL845092 | 0.82 | TP53 (0.41) | TP53THRB | |
| SCHEMBL845370 | 0.81 | PIK3CA (0.37) | HCRTR1HCRTR2THRBPIK3CAMTOR | |
| SCHEMBL10119511 | 0.81 | GAA (0.44) | TP53ALDH1A1GAAMEN1TSHR | |
| SCHEMBL872636 | 0.81 | POLB (0.33) | BCHEACHEALDH1A1PIK3CAMTOR | |
| SCHEMBL874517 | 0.76 | THRB (0.36) | TP53THRB | |
| SCHEMBL845518 | 0.74 | GAA (0.52) | TP53ALDH1A1GAAMEN1TSHR | |
| SCHEMBL873095 | 0.72 | HDAC8 (0.38) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |