Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 3/20 | 0.35 |
| ▸ | SGK1 | O00141 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30853839 | 0.82 | HTR3A (0.44) | HTR2CHTR2AHTR2B | |
| SCHEMBL22382688 | 0.81 | RIPK1 (0.43) | HTR2CHTR2AHTR2BKDM1AMAOB | |
| SCHEMBL18741430 | 0.80 | ADRB1 (0.40) | HTR2CHTR2AHTR2BKDM1AALDH1A1 | |
| SCHEMBL5240098 | 0.79 | PDE4B (0.43) | HTR2CHTR2AHTR2BALDH1A1TSHR | |
| SCHEMBL410563 | 0.78 | P2RX7 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL470870 | 0.78 | P2RX7 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL18950390 | 0.78 | HTR2C (0.46) | HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL8588169 | 0.75 | HTR2C (0.46) | HTR2CHTR2AHTR2BKDM1AMAOB | |
| SCHEMBL7584443 | 0.74 | TDP1 (0.40) | HTR2CHTR2AHTR2BL3MBTL1 | |
| SCHEMBL7582143 | 0.73 | CHRM3 (0.41) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-A1 | PALLADIUM CATALYZED INDOLIZATION | Merck & Co., Inc. (US) | 1999-06-30 | — | — | EP | claimed |
| WO-1998006725-A1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | claimed |