Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KAT7 | O95251 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7582143 | 0.86 | CHRM3 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL7583073 | 0.83 | HTR2A (0.40) | TDP1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL470870 | 0.79 | P2RX7 (0.43) | TDP1HTR2AHTR2CHTR2BTAAR1 | |
| SCHEMBL410563 | 0.79 | P2RX7 (0.43) | TDP1HTR2AHTR2CHTR2BTAAR1 | |
| SCHEMBL18741430 | 0.78 | ADRB1 (0.40) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL30853839 | 0.76 | HTR3A (0.44) | HTR2AHTR2CHTR2B | |
| SCHEMBL22382688 | 0.76 | RIPK1 (0.43) | TDP1HTR2AHTR2CHTR2B | |
| SCHEMBL8458372 | 0.74 | AKT1 (0.39) | L3MBTL1HTR2AHTR2CHTR2B | |
| SCHEMBL7584116 | 0.72 | ADRA2C (0.38) | HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9226443 | 0.72 | ADRA2C (0.37) | HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |