Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.38 |
| ▸ | IKBKB | O14920 | 4/20 | 0.38 |
| ▸ | RARA | P10276 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458293 | 0.92 | IKBKB (0.39) | HIF1AIKBKBRARAEPAS1MEN1 | |
| SCHEMBL8458292 | 0.85 | IKBKB (0.41) | HIF1AIKBKBRARAEPAS1KMT2A | |
| SCHEMBL8457350 | 0.83 | EPHX2 (0.36) | HIF1AEPAS1EPHX2MEN1KMT2A | |
| SCHEMBL8458442 | 0.80 | IKBKB (0.42) | HIF1AIKBKBRARAEPAS1MEN1 | |
| SCHEMBL8458190 | 0.74 | DEGS1 (0.35) | HIF1AEPAS1EPHX2MEN1KMT2A | |
| SCHEMBL7926635 | 0.71 | IKBKB (0.48) | IKBKBRARAEPHX2MEN1KMT2A | |
| SCHEMBL8911209 | 0.71 | RARA (0.41) | RARAMEN1KMT2A | |
| SCHEMBL7926536 | 0.68 | IKBKB (0.50) | IKBKBRARAMEN1KMT2A | |
| SCHEMBL8575213 | 0.67 | RARA (0.54) | IKBKBRARAMEN1KMT2A | |
| SCHEMBL8434728 | 0.65 | RARA (0.60) | IKBKBRARAMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952382-A | INHIBITING THE BIOLOGICAL EFFECTS OF AN OVERREGULATION OF RETINOID ACID RECEPTORS AND/OR OF A HYPERVITAMINOSIS A; TREATING SKIN DISORDER, EYE VISION DEFECTS, SKIN AGING | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-09-14 | — | — | US | disclosed |