Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31614294 | 0.87 | MT-CO2 (0.55) | FOLH1METESR1MEN1GAA | |
| SCHEMBL27640937 | 0.87 | MT-CO2 (0.55) | FOLH1METESR1MEN1GAA | |
| SCHEMBL27823628 | 0.82 | MET (0.47) | FOLH1METESR1MEN1GAA | |
| SCHEMBL1202580 | 0.81 | AKR1C3 (0.47) | FOLH1METMEN1GAAKMT2A | |
| SCHEMBL11077471 | 0.74 | ALOX15 (0.50) | FOLH1METESR1MEN1GAA | |
| SCHEMBL1438719 | 0.74 | GAA (0.57) | FOLH1MEN1GAAKMT2AALOX15 | |
| SCHEMBL8459765 | 0.73 | FOLH1 (0.50) | FOLH1METESR1MEN1GAA | |
| SCHEMBL28833648 | 0.73 | GAA (0.42) | FOLH1METESR1MEN1GAA | |
| SCHEMBL11463161 | 0.72 | AKR1C3 (0.49) | FOLH1METMEN1GAAKMT2A | |
| SCHEMBL23693310 | 0.72 | ALOX15 (0.48) | MEN1GAAKMT2AALOX15CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906315-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049710-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-12-31 | — | — | WO | disclosed |