Sugi Predict

Sugi Predict / Compounds / SCHEMBL8464720

SCHEMBL8464720

SCHEMBL8464720

C[C@H](OCc1ccccc1)[C@@H](N)C(=O)O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC1A1 P43005 10/20 0.68
▸ SLC1A2 P43004 9/20 0.68
▸ SLC1A3 P43003 8/20 0.68
▸ MEN1 O00255 1/20 0.68
▸ CYP1A2 P05177 1/20 0.68
▸ CYP2D6 P10635 1/20 0.68
▸ CYP2C9 P11712 1/20 0.68
▸ CYP2C19 P33261 1/20 0.68
▸ KMT2A Q03164 1/20 0.68
▸ SLC15A1 P46059 1/20 0.49
▸ MMP9 P14780 2/20 0.47
▸ MMP8 P22894 2/20 0.47
▸ ALDH1A1 P00352 1/20 0.46
▸ ALPI P09923 1/20 0.46
▸ PKM P14618 1/20 0.46
▸ PTGS1 P23219 1/20 0.46
▸ XIAP P98170 1/20 0.46
▸ SLC7A5 Q01650 1/20 0.46
▸ LTA4H P09960 1/20 0.44
▸ RCE1 Q9Y256 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL288385 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
SCHEMBL31606672 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
SCHEMBL18325959 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
SCHEMBL14037383 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
SCHEMBL289127 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
SCHEMBL288386 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
SCHEMBL562232 1.00 SLC1A1 (0.68) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
Hydrochloric Acid SCHEMBL20820005 0.98 SLC1A1 (0.66) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
Hydrochloric Acid SCHEMBL15670199 0.98 SLC1A1 (0.66) SLC1A1SLC1A2SLC1A3MEN1CYP1A2
Hydrochloric Acid SCHEMBL3334189 0.98 SLC1A1 (0.66) SLC1A1SLC1A2SLC1A3MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115515937-A Dimers for the synthesis of peptidomimetics 范因斯坦医学研究院 2022-12-23 — — CN disclosed
US-20220169676-A1 INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES WASHINGTON UNIVERSITY (US) 2022-06-02 — — US disclosed
EP-3087094-B1 BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS POLYPHOR AG (CH) 2022-06-01 — — EP disclosed
EP-2852591-A1 L-MALATE SALT OF 2, 7 - DIAZA - SPIRO [4.5]DEC- 7 - YLE DERIVATIVES AND CRYSTALLINE FORMS THEREOF AS GHRELIN RECEPTOR AGONISTS Novartis AG (CH) 2015-04-01 — — EP disclosed
US-20130331369-A1 3-Spirocyclic Piperidine Derivatives as Ghrelin Receptor Agonists NOVARTIS AG (CH) 2013-12-12 — — US disclosed
WO-2013164790-A1 L-MALATE SALT OF 2, 7 - DIAZA - SPIRO [4.5 ] DEC- 7 - YLE DERIVATIVES AND CRYSTALLINE FORMS THEREOF AS GHRELIN RECEPTOR AGONISTS NOVARTIS AG (CH) 2013-11-07 — — WO disclosed
US-20130296358-A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS NOVARTIS PHARMACEUTICALS UK LIMITED (GB) 2013-11-07 — — US disclosed
US-8546416-B2 3-spirocyclic piperidine derivatives as ghrelin receptor agonists NOVARTIS AG (CH) 2013-10-01 — — US disclosed
WO-2012164473-A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS NOVARTIS AG (CH) 2012-12-06 — — WO disclosed
US-20120302540-A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS NOVARTIS PHARMACEUTICALS UK LIMITED (GB) 2012-11-29 — — US disclosed
US-5859052-A TREATING LENTIVIRUS INFECTIONS, ESPECIALLY HUMAN IMMUNODEFICIENCY VIRUS G. D. SEARLE & CO. (US) 1999-01-12 — — US disclosed
US-5744631-A Fatty acid analogs and prodrugs G.D. SEARLE & CO. (US) 1998-04-28 — — US disclosed
US-5719290-A METHYLOXYUNDECYL- OR DECYLOXYETHYL-NITRILE OR TETRAZOLE DERIVATIVES; VIRICIDES G. D. SEARLE & CO. (US) 1998-02-17 — — US disclosed
US-5672769-A CHEMICAL INTERMEDIATES FOR VIRICIDES, FUNGICIDES G. D. SEARLE & CO. (US) 1997-09-30 — — US disclosed
US-5670650-A ANTIVIRAL AND ANTIFUNGAL AGENTS G. D. SEARLE & CO. (US) 1997-09-23 — — US disclosed
US-5599947-A VIRICIDES, FUNGICIDES OR THEIR PRODRUGS G. D. SEARLE & CO. (US) 1997-02-04 — — US disclosed
US-4745124-A THIO/ESTER PEPTIDES UNIVERSITY OF MIAMI (US) 1988-05-17 — — US disclosed
US-4690936-A AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS UNIVERSITY OF MIAMI (US) 1987-09-01 — — US disclosed
US-4127538-A ANALGESIC VETERANS ADMINISTRATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY 1978-11-28 — — US disclosed
US-4127521-A ANALGESIC VETERANS ADMINISTRATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY 1978-11-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130331369-A1 3-Spirocyclic Piperidine Derivatives as Ghrelin Receptor Agonists GIPR, GHSR, GLP1R SLC1A1 1381/4885SLC1A2 2041/4885SLC1A3 1777/4885
US-20220169676-A1 INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES HDGF, MMP7, HGF SLC1A1 4073/4885SLC1A2 4396/4885SLC1A3 4238/4885
US-20130296358-A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS GIPR, GHSR, GLP1R SLC1A1 1381/4885SLC1A2 2041/4885SLC1A3 1777/4885
US-20120302540-A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS GIPR, GHSR, GLP1R SLC1A1 1381/4885SLC1A2 2041/4885SLC1A3 1777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.