Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072870 | 0.83 | ALOX5 (0.55) | ALOX5KDRGPR84NQO2MAPKAPK2 | |
| SCHEMBL8086655 | 0.81 | ROCK2 (0.49) | ALOX5KDRMAPKAPK2CYP3A4ROCK2 | |
| SCHEMBL8082235 | 0.81 | ALOX5 (0.48) | ALOX5KDRNQO2MAPKAPK2PIK3CA | |
| SCHEMBL8467392 | 0.80 | RXFP1 (0.52) | ALOX5KDRGPR84MAPKAPK2SLC22A12 | |
| SCHEMBL8080761 | 0.80 | ALOX5 (0.48) | ALOX5MAPKAPK2ROCK2 | |
| SCHEMBL8084959 | 0.79 | ALOX5 (0.47) | ALOX5KDRGPR84NQO2MAPKAPK2 | |
| SCHEMBL8085101 | 0.78 | ALOX5 (0.52) | ALOX5KDRNQO2MAPKAPK2ROCK2 | |
| SCHEMBL8081908 | 0.77 | ALOX5 (0.49) | ALOX5NQO2MAPKAPK2PIK3CDPIK3CB | |
| SCHEMBL8085131 | 0.77 | ALOX5 (0.51) | ALOX5KDRNQO2MAPKAPK2ROCK2 | |
| SCHEMBL8086679 | 0.76 | ALOX5 (0.48) | ALOX5KDRNQO2MAPKAPK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |