Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8677604 | 0.97 | TSHR (0.33) | TSHR | |
| Methacrylic Acid SCHEMBL16401406 | 0.86 | ALDH1A1 (0.30) | TSHR | |
| SCHEMBL27561598 | 0.84 | — | — | |
| Methacrylic Acid SCHEMBL31531471 | 0.83 | ALDH1A1 (0.31) | TSHR | |
| SCHEMBL8677602 | 0.80 | TSHR (0.32) | TSHR | |
| Water SCHEMBL8373243 | 0.76 | TSHR (0.37) | TSHR | |
| SCHEMBL629318 | 0.70 | — | — | |
| SCHEMBL3973299 | 0.70 | — | — | |
| SCHEMBL9316704 | 0.70 | TSHR (0.37) | TSHR | |
| SCHEMBL218560 | 0.69 | TSHR (0.35) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639622-B1 | Silicone rubber with self-adhesion to glass and metal | DOW CORNING (US) | 1999-10-06 | — | — | EP | claimed |
| EP-0639622-A2 | Silicone rubber with self-adhesion to glass and metal | DOW CORNING CORPORATION (US) | 1995-02-22 | — | — | EP | claimed |
| US-5364921-A | Silicone rubber with self-adhesion to glass and metal | DOW CORNING CORPORATION (US) | 1994-11-15 | — | — | US | claimed |
| EP-4301318-A1 | PREPARATION OF A TINTED COSMETIC COMPOSITION | Coatex (FR) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022184985-A1 | PREPARATION OF A TINTED COSMETIC COMPOSITION | COATEX (FR) | 2022-09-09 | — | — | WO | disclosed |
| EP-3313907-A1 | POLYMER AS THICKENER AND SUSPENDING AGENT | COATEX (FR) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016207554-A1 | POLYMER AS THICKENER AND SUSPENDING AGENT | COATEX (FR) | 2016-12-29 | — | — | WO | disclosed |
| EP-3068745-A1 | FLUIDITY-RETAINING AGENT FOR HYDRAULIC COMPOSITIONS, COMPATIBLE WITH A WATER-REDUCING AGENT OF THE COMB POLYMER TYPE | COATEX (FR) | 2016-09-21 | — | — | EP | disclosed |