SCHEMBL8470772

SCHEMBL8470772

[O]c1ccc(F)cc1-c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.41
METAP2 P50579 1/20 0.40
BACE1 P56817 1/20 0.39
HTT P42858 1/20 0.39
LMNA P02545 2/20 0.39
HPGD P15428 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAOB P27338 1/20 0.39
TNKS O95271 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2A6 P11509 1/20 0.38
MAP2K4 P45985 1/20 0.38
AR P10275 1/20 0.38
PTGS1 P23219 2/20 0.36
PPARG P37231 1/20 0.36
PTGS2 P35354 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11665495 0.79 BACE1 (0.44) MAPTMETAP2BACE1CYP1A2CYP2A6
SCHEMBL3751706 0.78 MAPT (0.41) MAPTMETAP2BACE1HTTLMNA
SCHEMBL15509632 0.77 METAP2 (0.55) MAPTMETAP2BACE1HTTLMNA
SCHEMBL30997630 0.76 MAPT (0.45) MAPTMETAP2BACE1HTTLMNA
SCHEMBL6561402 0.76 PTGS2 (0.46) MAPTMETAP2BACE1PTGS1PTGS2
SCHEMBL28367566 0.74 METAP2 (0.40) MAPTMETAP2BACE1HTTLMNA
SCHEMBL1030329 0.74 BACE1 (0.46) MAPTMETAP2BACE1KDM4ECYP2A6
SCHEMBL29492484 0.74 ALDH1A1 (0.54) MAPTMETAP2BACE1HPGDALDH1A1
SCHEMBL21052203 0.74 ALDH1A1 (0.54) MAPTMETAP2BACE1HTTHPGD
SCHEMBL28820038 0.74 CYP2A6 (0.54) MAPTMETAP2BACE1HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6004954-A TREATING GRAFT-VERSUS-HOST DISEASE AND AUTOIMMUNE DISEASES; ANTIALLERGENS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-21 US disclosed