Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 8/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.67 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.67 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522929 | 0.84 | SIGMAR1 (0.69) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL1275831 | 0.80 | GRIN2B (1.00) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL5231157 | 0.77 | GRIN2B (0.54) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL9618307 | 0.76 | GRIN2B (0.67) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL4697155 | 0.76 | GRIN2B (0.67) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL1345544 | 0.75 | GRIN2D (0.56) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL45769 | 0.75 | GRIN2B (0.68) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL6313280 | 0.74 | GAA (0.41) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| Iodide SCHEMBL28653084 | 0.74 | GRIN2B (0.65) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL5586439 | 0.74 | GRIN2B (0.65) | GRIN2BGRIN1SIGMAR1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859190-A | SOLID PHASE SYNTHESIS TO FORM A PROTECTED DIPEPTIDE FOLLOWED BY REACTING WITH 1,1'-THIOCARBONYLDIIMIDAZOLE TO EFFECT RING FORMATION; EFFICIENCY; ANTICONVULSANT,-ARRHYTHMIC AND DIABETIC AGENTS; HERBICIDES AND FUNGICIDES | TREGA BIOSCIENCES, INC. (US) | 1999-01-12 | — | — | US | claimed |
| WO-1998033776-A1 | COMBINATORIAL LIBRARIES OF HYDANTOIN AND THIOHYDANTOIN DERIVATIVES, METHODS OF MAKING THE LIBRARIES AND COMPOUNDS THEREIN | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | claimed |
| US-5859190-A | SOLID PHASE SYNTHESIS TO FORM A PROTECTED DIPEPTIDE FOLLOWED BY REACTING WITH 1,1'-THIOCARBONYLDIIMIDAZOLE TO EFFECT RING FORMATION; EFFICIENCY; ANTICONVULSANT,-ARRHYTHMIC AND DIABETIC AGENTS; HERBICIDES AND FUNGICIDES | TREGA BIOSCIENCES, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998033776-A1 | COMBINATORIAL LIBRARIES OF HYDANTOIN AND THIOHYDANTOIN DERIVATIVES, METHODS OF MAKING THE LIBRARIES AND COMPOUNDS THEREIN | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | disclosed |