Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656725 | 0.77 | NR4A2 (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL8081515 | 0.77 | EDNRA (0.45) | KDM4EALDH1A1HPGDKMT2AEDNRA | |
| SCHEMBL8084890 | 0.76 | EDNRA (0.45) | KDM4EALDH1A1HPGDEDNRAEDNRB | |
| SCHEMBL7656191 | 0.76 | CFTR (0.47) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL8072530 | 0.75 | GPR35 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL27940177 | 0.74 | CTNNB1 (0.41) | SMN1; SMN2ALDH1A1HPGDKMT2APOLB | |
| SCHEMBL10431721 | 0.71 | FOLH1 (0.49) | KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL7659425 | 0.71 | PLAU (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7681510 | 0.70 | BACE1 (0.43) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7659665 | 0.70 | GRM2 (0.54) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948817-A | Polycyclic ethyl alkylamide melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998038991-A1 | POLYCYCLIC ETHYL ALKYLAMIDE MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-09-11 | — | — | WO | disclosed |