Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656725 | 0.90 | NR4A2 (0.45) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7662193 | 0.86 | ABL1 (0.44) | SMN1; SMN2CHEK2CHEK1 | |
| SCHEMBL7652482 | 0.85 | CHEK2 (0.47) | PLAUNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7659665 | 0.81 | GRM2 (0.54) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7681510 | 0.81 | BACE1 (0.43) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7656847 | 0.76 | AURKA (0.46) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7656191 | 0.76 | CFTR (0.47) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7652092 | 0.74 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGD | |
| SCHEMBL7658391 | 0.73 | MAPT (0.45) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL7657293 | 0.73 | UCHL1 (0.46) | PLAUNPC1RAB9AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340704-B1 | TREATING NERVE DISEASE OR BONE/JOINT DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-01-22 | — | — | US | disclosed |