Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | PRKCI | P41743 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.63 |
| ▸ | MMP3 | P08254 | 2/20 | 0.62 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.59 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.59 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18297788 | 0.89 | PRKCI (0.76) | PRKCIFGFR1MMP3HSD17B1HSD17B2 | |
| SCHEMBL16578698 | 0.87 | PRKCI (0.68) | ESR1MEN1KMT2APRKCIFGFR1 | |
| SCHEMBL4191589 | 0.87 | PRKCI (0.72) | PRKCIFGFR1ACMSDCYP2C9AGXT | |
| SCHEMBL14568511 | 0.85 | HSD17B1 (0.60) | ESR1PRKCIFGFR1MMP3HSD17B1 | |
| SCHEMBL3007832 | 0.85 | ESR1 (0.67) | ESR1PRKCIFGFR1MMP3HSD17B1 | |
| SCHEMBL249824 | 0.85 | PRKCI (0.70) | PRKCIFGFR1ACMSDAGXT | |
| SCHEMBL30108284 | 0.85 | PRKCI (0.70) | PRKCIFGFR1ACMSDAGXT | |
| SCHEMBL23750160 | 0.83 | PRKCI (0.63) | ESR1MEN1KMT2APRKCIFGFR1 | |
| SCHEMBL28011375 | 0.83 | FGFR1 (0.49) | ESR1MEN1KMT2APRKCIFGFR1 | |
| Benzyl Alcohol SCHEMBL28229622 | 0.83 | MMP3 (0.68) | ESR1MEN1KMT2AFGFR1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139548-B2 | Polycyclic derivatives, preparation process and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2015-09-22 | — | — | US | disclosed |
| US-20150005282-A1 | POLYCYCLIC DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2015-01-01 | — | — | US | disclosed |
| WO-2013104257-A1 | POLYCYCLIC DERIVATIVES, PREPARATION METHOD AND MEDICAL USES THEREOF | 江苏恒瑞医药股份有限公司 (CN) | 2013-07-18 | — | — | WO | disclosed |
| WO-2007034325-A1 | CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2007-03-29 | — | — | WO | disclosed |
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005282-A1 | POLYCYCLIC DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | GPR119, GPR55, GPR65 | ESR1 432/4885MEN1 1941/4885KMT2A 4205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.