6-Methoxy-3,7-Dimethylisochroman-8-Ol

6-Methoxy-3,7-Dimethylisochroman-8-Ol

SCHEMBL8484233

COc1cc2c(c(O)c1C)COC(C)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
GAA P10253 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KDM4E B2RXH2 2/20 0.38
KLK7 P49862 1/20 0.38
KLK5 Q9Y337 1/20 0.38
ATM Q13315 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP3A4 P08684 1/20 0.36
ACHE P22303 3/20 0.36
POLB P06746 2/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
BLM P54132 1/20 0.36
CACNA1B Q00975 1/20 0.36
APBA1 Q02410 1/20 0.36
KMT2A Q03164 1/20 0.36
MCL1 Q07820 1/20 0.36
SAE1 Q9UBE0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6,8-Dimethoxy-3,7-Dimethylisochroman SCHEMBL8479086 0.84 ATM (0.41) ALDH1A1GAASMN1; SMN2KDM4EATM
SCHEMBL8486293 0.79 POLB (0.39) ALDH1A1GAASMN1; SMN2KDM4ETDP1
SCHEMBL8482498 0.78 ALDH1A1 (0.40) ALDH1A1GAASMN1; SMN2KDM4EATM
SCHEMBL31644105 0.77 ATM (0.50) ALDH1A1GAASMN1; SMN2KDM4EATM
SCHEMBL8480217 0.77 ALDH1A1 (0.39) ALDH1A1GAASMN1; SMN2KDM4EATM
SCHEMBL8483338 0.77 PTGS2 (0.35) ALDH1A1GAASMN1; SMN2ATMTDP1
SCHEMBL8485958 0.76 MAOA (0.31) MEN1KMT2AMAOA
SCHEMBL8483898 0.75 DRD1 (0.37) ALDH1A1GAASMN1; SMN2
SCHEMBL8485301 0.74 ALDH1A1 (0.35) ALDH1A1GAASMN1; SMN2KDM4EKMT2A
SCHEMBL8484366 0.74 FASN (0.40) ALDH1A1GAAKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922889-A REACTING 3,7-DIMETHYL-6,8-DIMETHOXYISOCHROMAN WITH SODIUM ETHYL THIOLATE OR SODIUM HYDRIDE TO PRODUCE 3,7-DIMETHYL-6-HYDROXY-8-METHOXYISOCHROMAN; POSSESS PHYTOTOXIC ACTIVITY USED AS A BIODEGRADABLE HERBICIDE THE UNITED STATES OD AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1999-07-13 US claimed
US-5922889-A REACTING 3,7-DIMETHYL-6,8-DIMETHOXYISOCHROMAN WITH SODIUM ETHYL THIOLATE OR SODIUM HYDRIDE TO PRODUCE 3,7-DIMETHYL-6-HYDROXY-8-METHOXYISOCHROMAN; POSSESS PHYTOTOXIC ACTIVITY USED AS A BIODEGRADABLE HERBICIDE THE UNITED STATES OD AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1999-07-13 US disclosed