Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 12/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486928 | 1.00 | NAPRT (0.48) | NAPRTNFE2L2KDM4ETRIM24TRIM33 | |
| SCHEMBL31095185 | 0.88 | NFE2L2 (0.53) | NAPRTNFE2L2KDM4ETRIM24TRIM33 | |
| SCHEMBL31095207 | 0.86 | HSD11B1 (0.43) | NAPRTNFE2L2KDM4ETRIM24TRIM33 | |
| SCHEMBL31095224 | 0.86 | HSD11B1 (0.43) | NAPRTNFE2L2KDM4ETRIM24TRIM33 | |
| SCHEMBL20959864 | 0.83 | NPC1 (0.57) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL30632983 | 0.82 | NAPRT (0.36) | NAPRTNFE2L2KDM4ETRIM24TRIM33 | |
| SCHEMBL16343065 | 0.81 | — | — | |
| SCHEMBL29576848 | 0.81 | — | — | |
| SCHEMBL7216964 | 0.81 | — | — | |
| SCHEMBL172054 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869482-A | Dipyridio 2,3-b:3',2'-! azepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACUETICALS, INC. (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1998020002-A1 | DIPYRIDO[2,3-B:3',2'-F]AZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1998-05-14 | — | — | WO | disclosed |