SCHEMBL8488103

SCHEMBL8488103

N#Cc1ccc(C[CH]C(=O)N2CCN(C(=O)C(N)=O)CC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
FAAH O00519 1/20 0.39
IDO1 P14902 2/20 0.39
GPR183 P32249 1/20 0.39
EPHX1 P07099 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
TSHR P16473 1/20 0.38
KMT2A Q03164 1/20 0.38
DPP4 P27487 4/20 0.38
DPP8 Q6V1X1 2/20 0.38
FAP Q12884 1/20 0.38
DPP9 Q86TI2 1/20 0.38
DPP7 Q9UHL4 1/20 0.38
CYP2D6 P10635 1/20 0.38
HTT P42858 1/20 0.38
KCNJ1 P48048 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4423181 0.85 ALDH1A1 (0.49) ALDH1A1KDM4EL3MBTL1FAAHMEN1
SCHEMBL8485006 0.85 FAAH (0.43) ALDH1A1FAAHIDO1GPR183EPHX1
SCHEMBL7021128 0.83 CNR1 (0.43) ALDH1A1L3MBTL1FAAHIDO1GPR183
SCHEMBL6161203 0.82 MAPK1 (0.40) ALDH1A1GPR183MEN1KMT2AMAPK1
SCHEMBL7029546 0.82 OPRM1 (0.44) ALDH1A1CYP2C9TSHRCYP2D6CYP3A4
SCHEMBL8486359 0.76 THRB (0.47) L3MBTL1MEN1TSHRKMT2AMAPK1
SCHEMBL8489769 0.72 DPP4 (0.38) FAAHIDO1EPHX1DPP4DPP8
SCHEMBL8486345 0.70 KCNJ1 (0.38) FAAHEPHX1DPP4DPP8FAP
SCHEMBL7026731 0.70 POLB (0.44) FAAHDPP4DPP8FAPDPP9
SCHEMBL4420267 0.68 ITGB3 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5985899-A ANTICOAGULANTS LG CHEMICAL LTD. (KR) 1999-11-16 US disclosed
WO-1997049673-A1 SELECTIVE THROMBIN INHIBITORS LG CHEMICAL LTD. (KR) 1997-12-31 WO disclosed