Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 7/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500218 | 0.88 | THRA (0.36) | TDP1L3MBTL1ALDH1A1ESR1ESR2 | |
| SCHEMBL8501370 | 0.86 | L3MBTL1 (0.48) | NPBWR1TDP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL8499017 | 0.83 | AKR1C3 (0.39) | NPBWR1ERN1PTGS2PTGS1KDM4E | |
| SCHEMBL8496759 | 0.81 | ALDH1A1 (0.39) | NPBWR1ERN1PTGS2PTGS1KDM4E | |
| SCHEMBL8500428 | 0.81 | ESR1 (0.41) | TDP1L3MBTL1ALDH1A1ESR1ESR2 | |
| SCHEMBL7184010 | 0.81 | ESR1 (0.43) | NPBWR1ERN1PTGS2KDM4EALDH1A1 | |
| SCHEMBL7184005 | 0.81 | ESR1 (0.43) | NPBWR1ERN1PTGS2KDM4EALDH1A1 | |
| SCHEMBL7182545 | 0.80 | ESR1 (0.52) | KDM4EALDH1A1ESR1ESR2 | |
| SCHEMBL7182554 | 0.80 | ESR1 (0.52) | KDM4EALDH1A1ESR1ESR2 | |
| SCHEMBL7935041 | 0.80 | ADORA2A (0.45) | NPBWR1ERN1PTGS2PTGS1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |