Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11568319 | 0.84 | PNMT (0.40) | PNMTSLC6A4SIGMAR1 | |
| SCHEMBL4419129 | 0.82 | PNMT (0.53) | PNMTIDO1TAAR1SLC6A3SLC6A2 | |
| SCHEMBL26649158 | 0.79 | PNMT (0.59) | PNMTIDO1TAAR1SLC6A3SLC6A2 | |
| SCHEMBL11567658 | 0.79 | ALDH1A1 (0.46) | POLB | |
| SCHEMBL11565787 | 0.78 | PNMT (0.49) | PNMTIDO1TAAR1SLC6A3SLC6A2 | |
| SCHEMBL11683459 | 0.77 | VCAM1 (0.53) | POLB | |
| SCHEMBL11682445 | 0.77 | TSHR (0.47) | — | |
| SCHEMBL11566096 | 0.77 | HSD17B10 (0.39) | SLC6A2SLC6A4POLBSMN1; SMN2ALOX15 | |
| SCHEMBL8499045 | 0.76 | PNMT (0.55) | PNMTIDO1TAAR1 | |
| SCHEMBL9841199 | 0.74 | PNMT (0.45) | PNMTIDO1DPP4FAPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952328-A | MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES | CEPHALON, INC. (US) | 1999-09-14 | — | — | US | disclosed |