SCHEMBL8499772

SCHEMBL8499772

CC(=O)NC(CCCCCCc1ccccc1)(COC(C)=O)COC(C)=O

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
RECQL P46063 2/20 0.42
MAPT P10636 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
HDAC1 Q13547 2/20 0.41
ALOX5 P09917 1/20 0.41
HDAC2 Q92769 1/20 0.41
THRB P10828 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
FAAH O00519 3/20 0.40
CES1 P23141 3/20 0.40
POLB P06746 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
LMNA P02545 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
LTB4R Q15722 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8499575 1.00 ALDH1A1 (0.43) ALDH1A1RECQLMAPTRXFP1HDAC1
SCHEMBL8496246 1.00 ALDH1A1 (0.43) ALDH1A1RECQLMAPTRXFP1HDAC1
SCHEMBL8496895 0.92 LMNA (0.41) ALDH1A1RECQLTHRBTAAR1LMNA
SCHEMBL6503482 0.91 HDAC2 (0.45) HDAC1HDAC2FAAH
SCHEMBL5035787 0.89 ALDH1A1 (0.47) ALDH1A1RECQLMAPTTHRBTAAR1
SCHEMBL5035826 0.89 ALDH1A1 (0.47) ALDH1A1RECQLMAPTTHRBTAAR1
SCHEMBL8499864 0.88 TNNC1 (0.45) ALDH1A1MAPTTHRBFAAHLMNA
SCHEMBL8498944 0.88 TNNC1 (0.45) ALDH1A1MAPTTHRBFAAHLMNA
SCHEMBL8499405 0.88 TNNC1 (0.42) ALDH1A1MAPTTHRBFAAHPOLB
SCHEMBL8496902 0.88 TNNC1 (0.45) ALDH1A1MAPTTHRBFAAHLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952316-A FOR TREATING AUTOIMMUNE DISEASES, E.G., RHEUMATIOD ARTHRITIS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-09-14 US disclosed
EP-0627406-B1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL (JP) 1998-10-28 EP disclosed
US-5719176-A 2-amino-1,3-propanediol compound and immunosuppressant YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-02-17 US disclosed
US-5604229-A 2-amino-1,3-propanediol compound and immunosuppressant YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-02-18 US disclosed
EP-0627406-A1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-12-07 EP disclosed